Rewriting Life’s Blueprint: Antiphage Reverse Transcriptase and the Rise of Protein-Templated DNA

Authors

  • Dr Saima Usman Author
  • Prof Ahmad Waseem Author

Author Biographies

  • Dr Saima Usman

       Dr. Saima Usman is a molecular oncologist and oral pathology expert with a PhD and postdoctoral training from Queen Mary University of London, UK. She serves as Assistant Professor at the National University of Medical Sciences (NUMS), Pakistan, and is Director of Research at FRIS Charity UK. Her research focuses on epithelial cancers, cancer stem cells, vimentin intermediate filaments, and saliva-based non-invasive diagnostics, with over 20 peer-reviewed publications in high-impact journals such as eLife, Cells, and Cancers. Internationally recognized for her work on the C328S mutant vimentin and its role in breast cancer aggressiveness, she combines clinical practice with translational oncology research. Dr. Usman has supervised postgraduate projects on biomarkers in oral squamous cell carcinoma, secured competitive research funding, and actively collaborates with teams in the UK, USA, KSA, and UAE. She played a key role in establishing ‘Friends Researchers in the Indian Subcontinent’, a charity designed to encourage and support collaboration between the researchers of UK/EU and those based in the Indian subcontinent. She is the ‘Director of Research’ at this organization. She is also the Managing Editor of FRIS Horizons, a magazine which supports researchers from the South Asian subcontinent in building global collaborations.

  • Prof Ahmad Waseem

    Professor Ahmad Waseem is Emeritus Professor of Molecular and Cellular Oral Biology at Queen Mary University of London, widely recognized for his pioneering work on keratin biology, cytoskeletal proteins, and cancer biomarkers. After earning his PhD in Biochemistry from Aligarh Muslim University in 1982, he completed postdoctoral research at the University of Chicago, where he discovered adducin, a novel cytoskeletal protein complex. His career in the UK began at the Imperial Cancer Research Fund before moving into academia at King’s College London and later Queen Mary, where he rose to professorship in 2015. Professor Waseem’s research has illuminated the role of keratins in stem cell biology, wound healing, and squamous cell carcinoma, with significant contributions to understanding epithelial-mesenchymal transition in oral and skin cancers. He has published extensively in leading journals, supervised numerous PhD students, and received the Queen Mary ADEPT Fellowship for teaching excellence. In 2023 Prof Waseem established ‘Friends of Researchers in the Indian Subcontinent’, a charity designed to encourage and support collaboration between the researchers of UK/EU and those based in the Indian subcontinent. His legacy includes advancing oral biology research, mentoring future scientists, and fostering international collaborations.

References

Deng, P., H. Lee, C. Armijo, H. Wang, and A. Gao. Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase. Science. 0:eaed1656. DOI: 10.1126/science.aed1656.

Published

2026-07-01

Issue

Section

D. Contributions from readers: • Laboratory experiences • Reviews • Essays • Short stories • Thoughts for the day